Evaluation of Physical Stability of Phaleria Macrocarpa’s Leaf Extract Formulated in Nanoemulgel

Background: Phaleria macrocarpa’s leaf contains alkaloids, saponins, phenols, tannins, and flavonoids which have antioxidant, anti-inflammatory, antibacterial activities. The nanoemulgel preparation was chosen because it can penetrate well quickly into the mucosa thereby increasing absorption. Physical stability tests need to be carried out ensure quality, safety benefits of gel meet expected specifications stable during storage. Objective: This study aims determine concentration has most physical pH viscosity were observed for 28 days. Materials Methods: an experimental laboratory design, with 30 divided 3 groups, group 30%, 40%, 50% leaves macrocarpa. tested days every 7 in climatic chamber. among groups compared analyzed by Repeated Anova Pos Hoc test. Results: Average test 30% average baseline h+28 values 5,02 4,97 1610 cPas 1520 cPas. results value at = 4,65 4,60. mean value=1290 h+28=1170 post-Wilcoxon showed p>0.05 that there no significant difference a It means relatively constant from h+28. Conclusion: concluded macrocarpa concentrations 40% 50%.